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CBD Research News

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Learn about the latest news and trends in cannabidiol research:

Increasing interest in the use of CBD to help patients with pain, cardiovascular issues, decreasing blood pressure and reducing anxiety, as well as having beneficial effects on other medical conditions has led to an increase in academic research on these compounds. This site will focus on sharing current research, funding, facilities and project development news in the industry.

Background:

Cannabinoids tend to be highly lipophilic, allowing access to intracellular sites of action, resulting in increases in calcium in a variety of cell types, including hippocampal neurons. CBD cannabidiol pharmacological effects are controlled through two types of G protein coupled receptors:

 

  • Cannabinoid type I (CB 1 ).

  • Cannabinoid type II (CB 2 ), which are highly expressed in the hippocampus and other parts of the central nervous system (2).

  • CB 1 receptors slow down neurotransmission through action on calcium and potassium channels, which are known to modulate epileptiform and seizure activity (3).

  • CB 2 receptors are primarily expressed in the immune system and have limited expression in the central nervous system.

  • The effects of CBD are CB 2 receptor independent (3).

  • CBD has a low affinity for the CB 1 receptors, but even at low concentrations, CBD decreases G-protein activity (3).

  • CB 1 receptors are seen on many glutamatergic synapses that have been implicated in seizure threshold modulation.

  • CBD may act at CB 1 receptors to inhibit glutamate release (4).

  • Studies have shown changes in the expression of CB 1 receptors during epileptogenesis and after recurrent seizures (5).

  • CB 1 receptor expression is upregulated at GABAergic synapses and shown to be downregulated at glutamatergic synapses in epilepsy, contributing to lowering seizure thresholds.‚Äč

  • Other targets for CBD include transient receptor potential (TRP) channels that are involved with themodulation of intracellular calcium (1, 6).

  • CBD actions on calcium homeostasis may provide a basis for CBD neuroprotective properties.

Recent Research Updates: